PXD045176

PXD045176 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of ERK binding protein in S2 cells treated with Akh
Description	In addition to insulin resistance, enhanced response of insulin counter-regulatory hormones such as glucagon and its Drosophila homolog, adipokinetic hormone (Akh), has been shown to cause high-caloric diet-induced hyperglycemia across species. Many groups including ours have previously characterized regulatory components transducing linear Akh signaling that promotes carbohydrate production through glycogenolysis and gluconeogenesis. The spatial elucidation of Akh action at the organelle levels, however, still remains largely unknown. In this study, we revealed that Akh phosphorylates ERK and translocates it to peroxisome, mediates fat body peroxisomal conversion of amino acids from circulation into carbohydrate for subsequent gluconeogenesis in response to Akh.
HostingRepository	iProX
AnnounceDate	2023-09-06
AnnouncementXML	Submission_2023-09-06_20:19:39.478.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaying Li
SpeciesList	scientific name: Drosophila melanogaster; NCBI TaxID: 7227;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-06 20:19:21	ID requested
⏵ 1	2023-09-06 20:19:39	announced

Dataset with its publication pending

submitter keyword: APEX2, ERK, S2 cell, Akh

Wei Song
contact affiliation	Wuhan University
contact email	songw@whu.edu.cn
lab head
Jiaying Li
contact affiliation	Wuhan University
contact email	jiayingli@whu.edu.cn
dataset submitter

iProX dataset URI