PXD045172

PXD045172 is an original dataset announced via ProteomeXchange.

Title	Hemolymph metabolites in the larvae with Akh gain-of-function
Description	In addition to insulin resistance, enhanced response of insulin counter-regulatory hormones such as glucagon and its Drosophila homolog, adipokinetic hormone (Akh), has been shown to cause high-caloric diet-induced hyperglycemia across species. Many groups including ours have previously characterized regulatory components transducing linear Akh signaling that promotes carbohydrate production through glycogenolysis and gluconeogenesis. The spatial elucidation of Akh action at the organelle levels, however, still remains largely unknown. In this study, we revealed that Akh phosphorylates ERK and translocates it to peroxisome, mediates fat body peroxisomal conversion of amino acids from circulation into carbohydrate for subsequent gluconeogenesis in response to Akh.
HostingRepository	iProX
AnnounceDate	2023-09-06
AnnouncementXML	Submission_2023-09-06_20:12:25.313.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peixuan Dang
SpeciesList	scientific name: Drosophila melanogaster; NCBI TaxID: 7227;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-06 20:12:08	ID requested
⏵ 1	2023-09-06 20:12:25	announced

Dataset with its publication pending

submitter keyword: drosophila, hemolymph, hyperglycemia, metabolites

Wei Song
contact affiliation	Medical Research Institute, Wuhan University
contact email	songw@whu.edu.cn
lab head
Peixuan Dang
contact affiliation	Medical Research Institute, Wuhan University
contact email	peixuandangg@huedu.cn
dataset submitter

iProX dataset URI