PXD045159

PXD045159 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Impact of anesthetics on rat hippocampus and neocortex: a comprehensive proteomic study based on label-free mass spectrometry
Description	In this work, in vivo experiment simulating a general anesthesia and ICU sedation was designed to assess the impact of two intravenous (midazolam, dexmedetomidine) and two inhalational (isoflurane, desflurane) agents to neuronal centers for cognition (neocortex), learning, and memory (hippocampus). More than 3600 proteins were quantified across both neocortex and hippocampus. Proteomic study revealed relatively mild effects of anesthetics, nevertheless, protein dysregulation uncovered possible different effect of isoflurane (and midazolam) compared to desflurane (and dexmedetomidine) to neocortical and hippocampal proteins.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:42:08.693.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marie Vajrychová
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-06 08:45:44	ID requested
1	2024-05-23 01:12:00	announced
⏵ 2	2024-10-22 06:42:16	announced	2024-10-22: Updated project metadata.

Publication List

10.1016/j.heliyon.2024.e27638;
Astapenko D, Vajrychova M, Fabrik I, Kupcik R, Pimkova K, Tambor V, Radochova V, Cerny V, Impact of anesthetics on rat hippocampus and neocortex: A comprehensive proteomic study based on label-free mass spectrometry. Heliyon, 10(6):e27638(2024) [pubmed]

10.1016/j.heliyon.2024.e27638;

Astapenko D, Vajrychova M, Fabrik I, Kupcik R, Pimkova K, Tambor V, Radochova V, Cerny V, Impact of anesthetics on rat hippocampus and neocortex: A comprehensive proteomic study based on label-free mass spectrometry. Heliyon, 10(6):e27638(2024) [pubmed]

Keyword List

submitter keyword: hippocampus, neocortex, long-term potentiation, anesthetics, GABA signaling, VDAC, apoptosis, NMDAR,Label-free proteomics

submitter keyword: hippocampus, neocortex, long-term potentiation, anesthetics, GABA signaling, VDAC, apoptosis, NMDAR,Label-free proteomics

Contact List

Marie Vajrychova
contact affiliation	University Hospital Hradec Kralove
contact email	marie.vajrychova@fnhk.cz
lab head
Marie Vajrychová
contact affiliation	Biomedical Research Center, University Hospital Hradec Králové
contact email	marie.vajrychova@fnhk.cz
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD045159
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD045159

PRIDE project URI

Repository Record List

[ + ]