PXD045118

PXD045118 is an original dataset announced via ProteomeXchange.

Title	Phosphorylation of Bcl-xL by ERK1
Description	The anti-apoptotic function of Bcl-xL in the heart against reperfusion injury is diminished by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows dissociation of Bcl-xL from Bax and promotes cardiomyocyte death. Here we show that Ser14 phosphorylation of Bcl-xL is also promoted by hemodynamic stress in the heart, through the H-Ras-ERK pathway. Our study suggests that phosphorylation of Bcl-xL at Ser14 in response to acute pressure overload plays an essential role in mediating compensatory hypertrophy by promoting calcium release, alleviating the negative constraint of Bcl-xL upon the IP3R-NFAT pathway.
HostingRepository	PRIDE
AnnounceDate	2023-09-06
AnnouncementXML	Submission_2023-09-06_08:43:55.368.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD045118
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	MichinariNakamura
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-05 13:28:45	ID requested
⏵ 1	2023-09-06 08:43:55	announced

10.6019/PXD045118;

submitter keyword: Human, phosphorylation, Mitogen-activated protein kinase 3, Bcl-2-like protein 1

MichinariNakamura
contact affiliation	Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Rutgers Biomedical and Health Sciences
contact email	nakamumi@njms.rutgers.edu
lab head
MichinariNakamura
contact affiliation	Rutgers
contact email	nakamumi@njms.rutgers.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD045118
     1. Label: PRIDE project
     2. Name: Phosphorylation of Bcl-xL by ERK1