PXD045095

PXD045095 is an original dataset announced via ProteomeXchange.

Title	Competitive colonization of Akkermansia muciniphila clades by microbial extracellular vesicles through direct inhibition and immune stimulation
Description	Akkermansia muciniphila, a candidate for next-generation probiotics, can be classified into several clades with distinct genomic divergence. However, the global distribution and population structure of clade-typed A. muciniphila remain poorly understood. Here, we report on the predominance of single A. muciniphila clades in humans globally. We found that the predominance of the A. muciniphila clade is dynamically regulated by the balance between inter-clade inhibitory and pre-occupancy effects. A. muciniphila clade II (AmII)-derived extracellular vesicles exhibited a unilateral inhibitory effect on the growth of AmI. Clade-specific IgA responses were induced by each clade. AmII clade-specific IgAs, also induced by extracellular vesicles, facilitate the competitive exclusion of AmI. Our findings help toward the development of personalized intervention strategies for A. muciniphila, considering a subject’s A. muciniphila type.
HostingRepository	PRIDE
AnnounceDate	2025-02-11
AnnouncementXML	Submission_2025-02-11_00:49:13.100.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Moon-Gi Hong
SpeciesList	scientific name: Akkermansia muciniphila; NCBI TaxID: 239935;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-04 21:36:56	ID requested
⏵ 1	2025-02-11 00:49:13	announced

Dataset with its publication pending

submitter keyword: extracellular vesicles,Akkermansia muciniphila, immune stimulation

Young-Do Nam
contact affiliation	Research Group of Personalized Diet, Korea Food Research Institute
contact email	youngdo98@kfri.re.kr
lab head
Moon-Gi Hong
contact affiliation	R&D Center, Enterobiome Inc., 814 Siksa-dong, Ilsandong-gu, Goyang-si 10326, Republic of Korea
contact email	mghong@enterobiome.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD045095

PRIDE project URI

• PRIDE
  1. PXD045095
     1. Label: PRIDE project
     2. Name: Competitive colonization of Akkermansia muciniphila clades by microbial extracellular vesicles through direct inhibition and immune stimulation