PXD045079

PXD045079 is an original dataset announced via ProteomeXchange.

Title	The inhibitor protein IF1 from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex
Description	The hydrolytic activity of the ATP synthase in bovine mitochondria is inhibited by a protein called IF1, but bovine IF1 has no effect on the synthetic activity of the bovine enzyme in mitochondrial vesicles in the presence of a proton motive force. As part of an investigation into the inhibitory effects on the hydrolytic and synthetic activities of ATP synthase in bovine sub-mitochondrial particles, the absolute quantities of both the ATP synthase complex and the IF1 protein have been measured.
HostingRepository	PRIDE
AnnounceDate	2024-01-29
AnnouncementXML	Submission_2024-01-29_06:41:58.147.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ian M. Fearnley
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-04 05:22:49	ID requested
⏵ 1	2024-01-29 06:41:59	announced

Carroll J, Watt IN, Wright CJ, Ding S, Fearnley IM, Walker JE, from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex. J Biol Chem, 300(3):105690(2024) [pubmed]

10.1016/j.jbc.2024.105690;

submitter keyword: bovine mitochondria, ATP synthase, IF1 protein, absolute quantification

John E. Walker
contact affiliation	Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge UK
contact email	walker@mrc-mbu.cam.ac.uk
lab head
Ian M. Fearnley
contact affiliation	Medical Research Council Mitochondrial Biology Unit University of Cambridge
contact email	imf@mrc-mbu.cam.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD045079
     1. Label: PRIDE project
     2. Name: The inhibitor protein IF1 from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex