PXD045061
PXD045061 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella |
Description | The intracellular protozoan Eimeria tenella is responsible for avian coccidiosis which is characterized by intestinal injury. During developmental cycle, E. tenella undergoes versatile transitional stages such as oocyst, sporozoites, merozoites as well as gametocytes. These developmental transitions involved changes in cell shape and cell size requiring cytoskeletal remodeling and changes in membrane proteins, which may require transcriptional and translational regulations as well as post-translational modification of proteins. Palmitoylation is a post-translational modification (PTM) of protein that orchestrates protein targeting, folding, stability, regulated enzymatic activity and even epigenetic regulation of gene expression. Previous research revealed that protein palmitoylation play essential role in Toxoplasma gondii, Trypanosoma cruzi, Trichomonas vaginalis and several Plasmodium parasites. Up till now, there is little information on the enzymes related to palmitoylation and role of protein palmitoylation in pathogenic protozoan E. tenella. To analyze the role of protein palmitoylation within E. tenella, a palmitome of the second-generation merozoite of E. tenella was investigated. We identified a total of 2569 palmitoyl-sites that were assigned to 2145 palmitoyl-peptides belonging to 1561 protein-groups that participated in biological processes including parasite morphology, motility and host cell invasion. In addition, RNA biosynthesis, protein biosynthesis, folding, proteasome-ubiquitin degradation and enzymes involved in PTMs, carbohydrate metabolism, glycan biosynthesis and mitochondrial respiratory chain as well as vesicle trafficking were identified. The study allowed us to decipher the broad influence of palmitoylation on E. tenella biology, and thus lay a solid foundation to interpret its roles in the pathobiology of E. tenella infection. |
HostingRepository | iProX |
AnnounceDate | 2023-09-01 |
AnnouncementXML | Submission_2024-05-22_19:57:42.221.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zigang Qu |
SpeciesList | scientific name: Eimeria tenella; NCBI TaxID: 5802; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-09-03 19:02:24 | ID requested | |
1 | 2023-09-03 19:02:41 | announced | |
⏵ 2 | 2024-05-22 19:57:43 | announced | 2024-05-23: Update information. |
Publication List
Qu Z, Li Y, Li W, Zhang N, Olajide JS, Mi X, Fu B, Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella. Parasitol Res, 123(4):190(2024) [pubmed] |
Keyword List
submitter keyword: Palmitoylation |
E. tenella |
Biological process |
The second-generation merozoites |
Contact List
Zigang Qu | |
---|---|
contact affiliation | Lanzhou veterinary research institute, Chinese Academy of Agricultural Sciences |
contact email | quzigang@caas.cn |
lab head | |
Zigang Qu | |
contact affiliation | Lanzhou veterinary research institute, Chinese Academy of Agricultural Sciences |
contact email | quzigang@caas.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |