PXD044992 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Acetylomics on rhein treated NLRP3 activated J774A.1 macrophages |
Description | The aim of this project is to observe the effect of 5 μM rhein treatment on the acetylation level of NLRP3 activated macrophages. We primed J774A.1 cells with 100ng/mL LPS for 12 hours followed by 5μM rhein treatment for 30 minutes. Finally, the cells were stimulated with 4 mM ATP for 30 min to trigger the inflammasome assembly. Cell lysates were collected after ATP stimulation by cell scrapers, and acetylomics were performed as described below. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_02:44:34.058.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ruonan Zhou |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue |
Instrument | timsTOF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-31 02:16:17 | ID requested | |
⏵ 1 | 2024-10-17 02:44:34 | announced | |
Publication List
10.1038/s42003-024-06693-6; |
Zhou RN, Zhu ZW, Xu PY, Shen LX, Wang Z, Xue YY, Xiang YY, Cao Y, Yu XZ, Zhao J, Jin Y, Yan J, Yang Q, Fang PH, Shang WB, Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice. Commun Biol, 7(1):1003(2024) [pubmed] |
Keyword List
submitter keyword: Rhein, macrophage, NLRP3 inflammasome |
Contact List
Wenbin Shang |
contact affiliation | Key Laboratory for Metabolic Diseases in Chinese Medicine, Nanjing University of Chinese Medicine |
contact email | wbshang@hotmail.com |
lab head | |
Ruonan Zhou |
contact affiliation | Nanjing University of Chinese Medicine |
contact email | Ruonan.Zhou@njucm.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD044992 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044992
- Label: PRIDE project
- Name: Acetylomics on rhein treated NLRP3 activated J774A.1 macrophages