PXD044957

PXD044957 is an original dataset announced via ProteomeXchange.

Title	Complexome profiling of BRAWNIN KO mouse heart mitochondria
Description	BRAWNIN (BR) is a mitochondrial microprotein important for assembly of complex III. Here we used complexome to study the composition of supercomplexes in BR KO mouse heart mitochondria. BR deficiency induces the formation of a higher order electron transport chain complex which we renamed as extra-large supercomplex (SC-XL). The stoichiometry of SC-XL is I2+III2. SC-XL formation in the BR KO system alleviates the CIII defects and promotes compensatory OXPHOS increase. It is of higher electron transport efficiency and of lower ROS generation.
HostingRepository	PRIDE
AnnounceDate	2025-01-08
AnnouncementXML	Submission_2025-01-08_04:56:19.721.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-30 04:44:03	ID requested
⏵ 1	2025-01-08 04:56:20	announced

10.1016/J.CMET.2024.11.011;

submitter keyword: microproteins,Complexome profiling, mitochondria, supercomplexes

Lena Ho
contact affiliation	Cardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore
contact email	lena@ho-lab.org
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD044957

PRIDE project URI

• PRIDE
  1. PXD044957
     1. Label: PRIDE project
     2. Name: Complexome profiling of BRAWNIN KO mouse heart mitochondria