PXD044952

PXD044952 is an original dataset announced via ProteomeXchange.

Title	Deciphering early phosphoproteome changes in response to BMP9 and BMP10 in endothelial cells
Description	BMP9 and BMP10 are two key regulators of vascular homeostasis. These two ligands bind with high affinity to the endothelial type I receptor ALK1 together with a type 2 receptor. Mutations in this signaling pathway have been identified in two rare cardiovascular diseases, hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension. So far, only the canonical SMAD signaling pathway has been extensively studied in response to BMPs. The aim of this work was to address early phosphoproteomic changes in endothelial cells in response to short-term stimulation (30 mins) with BMP9 and BMP10 in order to identify new phosphorylated targets and signaling pathways.
HostingRepository	PRIDE
AnnounceDate	2024-03-25
AnnouncementXML	Submission_2024-03-25_09:56:55.770.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-30 03:22:48	ID requested
⏵ 1	2024-03-25 09:56:56	announced

10.1186/s12964-024-01486-0;

Al Tarrass M, Belmudes L, Ko, ç, a D, Azemard V, Liu H, Al Tabosh T, Ciais D, Desroches-Castan A, Battail C, Cout, é Y, Bouvard C, Bailly S, /P38 axis and cell cycle inhibition in response to BMP9 and BMP10 stimulation in endothelial cells. Cell Commun Signal, 22(1):158(2024) [pubmed]

submitter keyword: Vascular homeostasis, endothelial cells, signaling pathways, bone morphogenetic proteins, phosphoproteomics

Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
lab head
Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD044952
     1. Label: PRIDE project
     2. Name: Deciphering early phosphoproteome changes in response to BMP9 and BMP10 in endothelial cells