PXD044802 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Engineered skin microbiome-assisted delivery to the pilosebaceous unit |
Description | Microbes are fascinating molecular machines which can be equipped with synthetic genetic programs that allow them to produce therapeutic molecules targeted on demand upon disease sensing. Cutibacterium acnes engraftment capacity and its living habitat close to important pharmacological targets makes it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium, the most abundant commensal of the human skin, to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin in vivo, known to modulate cutaneous sebum production. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-10 |
AnnouncementXML | Submission_2023-11-10_08:51:29.850.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | EduardSabidó |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-23 09:08:57 | ID requested | |
⏵ 1 | 2023-11-10 08:51:30 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Cutibacterium acnes,microbiome, engineering |
Contact List
EduardSabido |
contact affiliation | Centre for Genomic Regulation, Universitat Pompeu Fabra |
contact email | eduard.sabido@crg.cat |
lab head | |
EduardSabidó |
contact affiliation | Centre de Regulació Genòmica |
contact email | eduard.sabido@crg.cat |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044802
- Label: PRIDE project
- Name: Engineered skin microbiome-assisted delivery to the pilosebaceous unit