PXD044777

PXD044777 is an original dataset announced via ProteomeXchange.

Title	De-obstruction of bladder outlet in humans reverses organ remodeling
Description	Bladder outlet obstruction (BOO) causes lower urinary tract symptoms and objectifiable urodynamic changes in bladder function. We carried out an integrated transcriptome and proteome analysis of bladder samples from male patients with BOO before and 3 months after de-obstruction surgery (transurethral resection of the prostate, TURP). mRNA and protein profiles were correlated with urodynamic findings, specifically voiding detrusor pressure (PdetQmax) before TURP. Patients with high PdetQmax showed less advanced remodeling and inflammatory changes than those with lower values. We oberved significant dysregulation of gene expression, which was reversed by de-obstruction in both patients’ groups. We propose a series of biomarker genes, indicative of BOO, and possibly contributing to the bladder changes. Our data sheds light on the stages of progressive obstruction-induced bladder decompensation, and might add selecting the operation point to avoid the loss of contractility.
HostingRepository	PRIDE
AnnounceDate	2024-05-21
AnnouncementXML	Submission_2024-05-21_07:16:39.153.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manfred Heller
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-23 01:50:51	ID requested
⏵ 1	2024-05-21 07:16:39	announced

10.1186/s12894-024-01417-8;

Akshay A, Gheinani AH, Besic M, Braga S, Uldry AC, Heller M, Rehrauer H, Fournier CA, Burkhard FC, Monastyrskaya K, De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors. BMC Urol, 24(1):33(2024) [pubmed]

submitter keyword: remodelling,bladder, fibrosis, outlet obstruction

Katia Monastyrskaya
contact affiliation	Functional Urology Research Lab, DBMR, University of Bern, 3008 Bern, Switzerland
contact email	katia.monastyrskaia@unibe.ch
lab head
Manfred Heller
contact affiliation	Proteomics and Mass Spectrometry Core Facility, Departement for Biomedical Research, University of Berne
contact email	pmscf.dbmr@unibe.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD044777

PRIDE project URI

• PRIDE
  1. PXD044777
     1. Label: PRIDE project
     2. Name: De-obstruction of bladder outlet in humans reverses organ remodeling