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PXD044760

PXD044760 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNeddylation of Insulin receptor substrate acts as a bona fide suppressor for cancer cell migration
DescriptionHyperinsulinemia, often associated with obesity and type 2 diabetes mellitus, is also linked to an elevated risk of various cancers. However, the specific mechanisms underlying this connection remain unclear. Here, we report that inhibiting neddylation, in the presence of insulin treatment, further promotes cancer cell migration in different cancer types by activating both insulin receptor substrate 1 and 2, as well as the PI3K/AKT signaling pathway. We also found that C-CBL neddylates IRS1 and IRS2 as an E3 ligase, with clinical evidence supporting its role as a tumor suppressor. Altogether, these findings suggest that the neddylation of IRS1 and IRS2 may be a bona fide suppressor of cancer cell migration. Thus, caution is advised when considering neddylation inhibitors as a treatment for cancer patients with obesity-related type 2 diabetes or hyperinsulinemic condition.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:41:05.151.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD044760
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAra Cho
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetic acid derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-22 23:55:46ID requested
12024-05-22 02:15:35announced
22024-10-22 06:41:07announced2024-10-22: Updated project metadata.
Publication List
10.6019/PXD044760;
Park JB, Moon GH, Cho A, Kwon M, Park JW, Yi EC, Kim H, Fukuda J, Kwak C, Ko YG, Chun YS, Neddylation of insulin receptor substrate acts as a bona fide regulator of insulin signaling and its implications for cancer cell migration. Cancer Gene Ther, 31(4):599-611(2024) [pubmed]
10.1038/s41417-024-00729-z;
Keyword List
submitter keyword: LC-MS/MS
Contact List
Eugene C. Yi
contact affiliationSeoul National University
contact emaileuyi@snu.ac.kr
lab head
Ara Cho
contact affiliationSeoul National University
contact emailara.cho@snu.ac.kr
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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