PXD044760 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Neddylation of Insulin receptor substrate acts as a bona fide suppressor for cancer cell migration |
Description | Hyperinsulinemia, often associated with obesity and type 2 diabetes mellitus, is also linked to an elevated risk of various cancers. However, the specific mechanisms underlying this connection remain unclear. Here, we report that inhibiting neddylation, in the presence of insulin treatment, further promotes cancer cell migration in different cancer types by activating both insulin receptor substrate 1 and 2, as well as the PI3K/AKT signaling pathway. We also found that C-CBL neddylates IRS1 and IRS2 as an E3 ligase, with clinical evidence supporting its role as a tumor suppressor. Altogether, these findings suggest that the neddylation of IRS1 and IRS2 may be a bona fide suppressor of cancer cell migration. Thus, caution is advised when considering neddylation inhibitors as a treatment for cancer patients with obesity-related type 2 diabetes or hyperinsulinemic condition. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:41:05.151.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD044760 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Ara Cho |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetic acid derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-22 23:55:46 | ID requested | |
1 | 2024-05-22 02:15:35 | announced | |
⏵ 2 | 2024-10-22 06:41:07 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.6019/PXD044760; |
Park JB, Moon GH, Cho A, Kwon M, Park JW, Yi EC, Kim H, Fukuda J, Kwak C, Ko YG, Chun YS, Neddylation of insulin receptor substrate acts as a bona fide regulator of insulin signaling and its implications for cancer cell migration. Cancer Gene Ther, 31(4):599-611(2024) [pubmed] |
10.1038/s41417-024-00729-z; |
Keyword List
submitter keyword: LC-MS/MS |
Contact List
Eugene C. Yi |
contact affiliation | Seoul National University |
contact email | euyi@snu.ac.kr |
lab head | |
Ara Cho |
contact affiliation | Seoul National University |
contact email | ara.cho@snu.ac.kr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044760
- Label: PRIDE project
- Name: Neddylation of Insulin receptor substrate acts as a bona fide suppressor for cancer cell migration