PXD044705 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Interactions of Histone Deacetylase 6 with DNA damage repair fac-tors strengthens its utility as a combination drug target in high-grade serous ovarian cancer |
Description | High-grade serous ovarian cancer (HGSOC) is the deadliest gynecologic malignancy in women.The lack of effective second line therapeutics remains a substantial challenge for BRCA-1/2 wildtype HGSOC patients, and contributes to poor survival rates due to drug resistance. There is a striking need to elucidate and implement new and alternative treatment options for patients with HGSOC. Histone Deacetylases (HDACs) are promising targets in HGSOC treat-ment, however, the mechanism and efficacy of HDAC inhibitors is understudied in HGSOC. In order to consider HDACs as a treatment target, we need to better understand how they are functioning within HGSOC. This includes elucidating HDAC6 protein-protein interactions. In this study, we carried out substrate trapping to elucidate HDAC6-specific interactors in the context of BRCA-1/2 wildtype HGSOC |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:18:57.732.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jolene Duda |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-21 11:26:06 | ID requested | |
1 | 2023-12-28 12:02:56 | announced | |
⏵ 2 | 2024-10-22 06:19:01 | announced | 2024-10-22: Updated project metadata. |
Publication List
Duda JM, Thomas SN, Interactions of Histone Deacetylase 6 with DNA Damage Repair Factors Strengthen its Utility as a Combination Drug Target in High-Grade Serous Ovarian Cancer. ACS Pharmacol Transl Sci, 6(12):1924-1933(2023) [pubmed] |
10.1021/acsptsci.3c00215; |
Keyword List
submitter keyword: LC-MS, ovarian cancer, hdacs, protein-protein interaction, histone deacetylase 6,human |
Contact List
Stefani N Thomas |
contact affiliation | Department of Laboratory Medicine and Patholoogy, University of Minnesota. Minneapolis, MN, USA |
contact email | stefanit@umn.edu |
lab head | |
Jolene Duda |
contact affiliation | University of Minnesota |
contact email | duda0032@umn.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD044705 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044705
- Label: PRIDE project
- Name: Interactions of Histone Deacetylase 6 with DNA damage repair fac-tors strengthens its utility as a combination drug target in high-grade serous ovarian cancer