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PXD044705

PXD044705 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInteractions of Histone Deacetylase 6 with DNA damage repair fac-tors strengthens its utility as a combination drug target in high-grade serous ovarian cancer
DescriptionHigh-grade serous ovarian cancer (HGSOC) is the deadliest gynecologic malignancy in women.The lack of effective second line therapeutics remains a substantial challenge for BRCA-1/2 wildtype HGSOC patients, and contributes to poor survival rates due to drug resistance. There is a striking need to elucidate and implement new and alternative treatment options for patients with HGSOC. Histone Deacetylases (HDACs) are promising targets in HGSOC treat-ment, however, the mechanism and efficacy of HDAC inhibitors is understudied in HGSOC. In order to consider HDACs as a treatment target, we need to better understand how they are functioning within HGSOC. This includes elucidating HDAC6 protein-protein interactions. In this study, we carried out substrate trapping to elucidate HDAC6-specific interactors in the context of BRCA-1/2 wildtype HGSOC
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:18:57.732.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJolene Duda
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-21 11:26:06ID requested
12023-12-28 12:02:56announced
22024-10-22 06:19:01announced2024-10-22: Updated project metadata.
Publication List
Duda JM, Thomas SN, Interactions of Histone Deacetylase 6 with DNA Damage Repair Factors Strengthen its Utility as a Combination Drug Target in High-Grade Serous Ovarian Cancer. ACS Pharmacol Transl Sci, 6(12):1924-1933(2023) [pubmed]
10.1021/acsptsci.3c00215;
Keyword List
submitter keyword: LC-MS, ovarian cancer, hdacs, protein-protein interaction, histone deacetylase 6,human
Contact List
Stefani N Thomas
contact affiliationDepartment of Laboratory Medicine and Patholoogy, University of Minnesota. Minneapolis, MN, USA
contact emailstefanit@umn.edu
lab head
Jolene Duda
contact affiliationUniversity of Minnesota
contact emailduda0032@umn.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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