PXD044700

PXD044700 is an original dataset announced via ProteomeXchange.

Title	The screening of cross-reactive targets of recombinant anti-collagen antibody R69-4
Description	Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 0.5% of the global population. Despite its prevalence, there is no known cure, underscoring the persistent need for novel therapeutic strategies. In previous studies, we identified a specific subset of antibodies that target an epitope (F4) on type-II collagen (COL2), which seemed to offer protection against arthritis. Leveraging these findings, we have engineered a range of recombinant antibodies against this epitope. Notably, one such antibody, R69-4, has shown significant potential in suppressing arthritis. Here, we aim to identify potential cross-reactive targets of R69-4 to better understand its mechanism of action.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:54:29.318.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susanna Lundström
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-21 08:21:19	ID requested
1	2023-09-05 03:41:28	announced
2	2023-09-28 11:07:09	announced	2023-09-28: Updated project metadata.
⏵ 3	2023-11-14 08:54:29	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Rheumatoid arthritis, antibodies

Roman Zubarev
contact affiliation	Division of chemistry I, Department of Medical Biochemistry & Biophysics, Karolinska Institutet
contact email	Roman.Zubarev@ki.se
lab head
Susanna Lundström
contact affiliation	Karolinska Institutet
contact email	susanna.lundstrom@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD044700

PRIDE project URI

• PRIDE
  1. PXD044700
     1. Label: PRIDE project
     2. Name: The screening of cross-reactive targets of recombinant anti-collagen antibody R69-4