PXD044699

PXD044699 is an original dataset announced via ProteomeXchange.

Title	Multifactorial neuroprotective effects of BNN27, a Nerve Growth Factor mimetic, in the 5xFAD mouse model of Alzheimer’s Disease
Description	Neurotrophic factors consist major regulatory molecules and their decline in Alzheimer's disease is considered as an important cause of disease progression. Novel pharmacological approaches are targeting the downstream pathways controlled by neurotrophins, such as nerve growth factor (NGF) receptors, TrkA and p75NTR, which enhance hippocampal neurogenic capacity and neuroprotective mechanisms, and potentially counteract the neurotoxic effects of amyloid depositions. In this context, BNN27 is a newly developed 17-spiro-steroid analog that have previously shown to mimic the neuroprotective effects of NGF, acting as selective activator of its receptors, both TrkA and p75NTR, promoting neuronal survival. Our present research work aims at determining whether and which aspects of the AD-related pathology, BNN27 is able to alleviate, exploring the cellular and molecular components and link these changes with improvements in the cognitive performance of a mouse AD model. Our results clearly indicate that BNN27 administration significantly reduced amyloid-β load in whole brain, enhanced adult hippocampal neurogenesis, restored cholinergic neurons function and synaptogenesis, reducing inflammatory activation and leading to significant restoration of cognitive functions.
HostingRepository	PRIDE
AnnounceDate	2024-11-25
AnnouncementXML	Submission_2024-11-25_03:36:44.331.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Evangelia Thanou
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-21 08:21:04	ID requested
⏵ 1	2024-11-25 03:36:44	announced

10.1038/S41380-024-02833-W;

submitter keyword: mouse, proteomics, brain, hippocampus, LC-MS, BNN27, 5xFAD, directDIA

Ka Wan Li
contact affiliation	Center for Neurogenomics and Cognitive Research, Department of Molecular and Cellular Neurobiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
contact email	k.w.li@vu.nl
lab head
Evangelia Thanou
contact affiliation	Center for Neurogenomics and Cognitive Research, Department of Molecular and Cellular Neurobiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
contact email	e.thanou@vu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD044699

PRIDE project URI

• PRIDE
  1. PXD044699
     1. Label: PRIDE project
     2. Name: Multifactorial neuroprotective effects of BNN27, a Nerve Growth Factor mimetic, in the 5xFAD mouse model of Alzheimer’s Disease