PXD044636 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Hydrogen Deuterium Exchange of PI4K(530-560) Peptide with Calcineurin |
Description | we used HDXMS to study if PI4KA(530-560) is able to bind calcineurin. Here we showed a significant protection in deuterium exchange upon binding calcineurin in the wild type state, indicating these proteins are interacting. Using a mutant that should inhibit the interaction (AKASAA), we showed that this mutant does in fact prevent protection by calcineurin. |
HostingRepository | PRIDE |
AnnounceDate | 2024-09-03 |
AnnouncementXML | Submission_2024-09-03_13:12:08.750.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | John Burke |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | impact HD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-18 08:34:08 | ID requested | |
⏵ 1 | 2024-09-03 13:12:20 | announced | |
Publication List
Shaw AL, Suresh S, Parson MAH, Harris NJ, Jenkins ML, Yip CK, Burke JE, Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A. Structure, ():(2024) [pubmed] |
10.1016/j.str.2024.08.007; |
Keyword List
submitter keyword: HDXMS, Pi4k, Calcineurin |
Contact List
Dr. John E. Burke |
contact affiliation | University of Victoria |
contact email | jeburke@uvic.ca |
lab head | |
John Burke |
contact affiliation | University of Victoria |
contact email | jeburke@uvic.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD044636 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044636
- Label: PRIDE project
- Name: Hydrogen Deuterium Exchange of PI4K(530-560) Peptide with Calcineurin