PXD044623

PXD044623 is an original dataset announced via ProteomeXchange.

Title	ABLs and TMKs are co-receptors for extracellular auxin
Description	Extracellular perception of auxin, an essential phytohormone in plants, has been debated for decades. Auxin binding protein 1 (ABP1) physically interacts with quintessential transmembrane kinases (TMKs) and was proposed to act as an extracellular auxin receptor, but its role was disputed because abp1 knockout mutants lack obvious morphological phenotypes. Here we identified two new auxin-binding proteins, ABL1 and ABL2, that are localized to the apoplast and directly interact with the extracellular domain of TMKs in an auxin-dependent manner. Furthermore, functionally redundant ABL1 and ABL2 genetically interact with TMKs and exhibit functions that are overlapping with those of ABP1 as well as independent of ABP1. Importantly, the extracellular domain of TMK1 itself binds auxin and synergizes with either ABP1 or ABL1 in auxin binding. Thus, our findings discovered new auxin receptors ABL1 and ABL2 having functions overlapping with but distinct from ABP1 and acting together with TMKs as co-receptors for extracellular auxin.
HostingRepository	PRIDE
AnnounceDate	2023-11-25
AnnouncementXML	Submission_2023-11-24_19:17:35.136.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	guochen qin
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-18 06:02:22	ID requested
⏵ 1	2023-11-24 19:17:35	announced

Yu Y, Tang W, Lin W, Li W, Zhou X, Li Y, Chen R, Zheng R, Qin G, Cao W, P, é, rez-Henr, í, quez P, Huang R, Ma J, Qiu Q, Xu Z, Zou A, Lin J, Jiang L, Xu T, Yang Z, ABLs and TMKs are co-receptors for extracellular auxin. Cell, 186(25):5457-5471.e17(2023) [pubmed]

10.1016/j.cell.2023.10.017;

submitter keyword: auxin receptor,arabidopsis

guochen qin
contact affiliation	Peking University Institute of Advanced Agricultural Sciences,
contact email	guochen.qin@pku-iaas.edu.cn
lab head
guochen qin
contact affiliation	Peking University Institute of Advanced Agricultural Sciences
contact email	guochen.qin@pku-iaas.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD044623

PRIDE project URI

• PRIDE
  1. PXD044623
     1. Label: PRIDE project
     2. Name: ABLs and TMKs are co-receptors for extracellular auxin