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PXD044623

PXD044623 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleABLs and TMKs are co-receptors for extracellular auxin
DescriptionExtracellular perception of auxin, an essential phytohormone in plants, has been debated for decades. Auxin binding protein 1 (ABP1) physically interacts with quintessential transmembrane kinases (TMKs) and was proposed to act as an extracellular auxin receptor, but its role was disputed because abp1 knockout mutants lack obvious morphological phenotypes. Here we identified two new auxin-binding proteins, ABL1 and ABL2, that are localized to the apoplast and directly interact with the extracellular domain of TMKs in an auxin-dependent manner. Furthermore, functionally redundant ABL1 and ABL2 genetically interact with TMKs and exhibit functions that are overlapping with those of ABP1 as well as independent of ABP1. Importantly, the extracellular domain of TMK1 itself binds auxin and synergizes with either ABP1 or ABL1 in auxin binding. Thus, our findings discovered new auxin receptors ABL1 and ABL2 having functions overlapping with but distinct from ABP1 and acting together with TMKs as co-receptors for extracellular auxin.
HostingRepositoryPRIDE
AnnounceDate2023-11-25
AnnouncementXMLSubmission_2023-11-24_19:17:35.136.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterguochen qin
SpeciesList scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-18 06:02:22ID requested
12023-11-24 19:17:35announced
Publication List
Yu Y, Tang W, Lin W, Li W, Zhou X, Li Y, Chen R, Zheng R, Qin G, Cao W, P, é, rez-Henr, í, quez P, Huang R, Ma J, Qiu Q, Xu Z, Zou A, Lin J, Jiang L, Xu T, Yang Z, ABLs and TMKs are co-receptors for extracellular auxin. Cell, 186(25):5457-5471.e17(2023) [pubmed]
10.1016/j.cell.2023.10.017;
Keyword List
submitter keyword: auxin receptor,arabidopsis
Contact List
guochen qin
contact affiliationPeking University Institute of Advanced Agricultural Sciences,
contact emailguochen.qin@pku-iaas.edu.cn
lab head
guochen qin
contact affiliationPeking University Institute of Advanced Agricultural Sciences
contact emailguochen.qin@pku-iaas.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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