PXD044611
PXD044611 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | SUMOylation fine tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis |
| Description | Reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine tuning the transcriptional activity of HEY1. Specifically, S UMOylation facilitates the formation of the HEY1 transcriptional complex and enhances its DNA binding capability in endothelial cells. |
| HostingRepository | iProX |
| AnnounceDate | 2023-08-18 |
| AnnouncementXML | Submission_2024-05-22_19:59:54.070.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ruizhe Ren |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-08-17 21:00:32 | ID requested | |
| 1 | 2023-10-07 00:32:16 | announced | |
| ⏵ 2 | 2024-05-22 19:59:54 | announced | 2024-05-23: Update information. |
Publication List
| Ren R, Ding S, Ma K, Jiang Y, Wang Y, Chen J, Wang Y, Kou Y, Fan X, Zhu X, Qin L, Qiu C, Simons M, Wei X, Yu L, SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis. Circ Res, 134(2):203-222(2024) [pubmed] |
Keyword List
| submitter keyword: SUMOylation, HEY1 , angiogenesis , transcription |
Contact List
| Luyang Yu | |
|---|---|
| contact affiliation | Zhejiang University |
| contact email | luyangyu@zju.edu.cn |
| lab head | |
| Ruizhe Ren | |
| contact affiliation | Zhejiang University |
| contact email | renrzmiracle@zju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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