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PXD044602

PXD044602 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures
DescriptionPost-translational modifications are key in the regulation of activity, structure, localization and stability of most proteins in eukaryotes. Phosphorylation is potentially the most studied post-translational modification, also due to its reversibility and thereby the regulatory role this modification often plays. While most research attention was focused on kinases in the past, phosphatases remain understudied, most probably because the addition and presence of the modification is more easily studied than its removal and absence. Here, we report the identification of an uncharacterized protein tyrosine phosphatase PPH-7 in C. elegans, a member of the evolutionary conserved PTPN family of phosphatases. Lack of PPH-7 function led to reduction of fertility and embryonic lethality at elevated temperatures. Proteomics revealed changes in the regulation of targets of the von Hippel Lindau (VHL) E3 ligase, suggesting a potential role for PPH-7 in the regulation of VHL.
HostingRepositoryMassIVE
AnnounceDate2024-01-29
AnnouncementXMLSubmission_2024-01-29_23:08:22.479.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterdanilo ritz
SpeciesList scientific name: Caenorhabditis elegans; common name: roundworm; NCBI TaxID: 6239;
ModificationListPhospho
InstrumentOrbitrap Fusion Lumos; Orbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-16 01:24:50ID requested
12024-01-29 23:08:22announced
Publication List
no publication
Keyword List
submitter keyword: phosphatase, protein tyrosine phosphatase, C. elegans
Contact List
Alexander Schmidt
contact affiliationBiozentrum, Universtiy of Basel, 4056 Basel, Switzerland
contact emailalex.schmidt@unibas.ch
lab head
danilo ritz
contact affiliationUniversity of Basel
contact emaildanilo.ritz@unibas.ch
dataset submitter
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Dataset FTP location
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