PXD044505

PXD044505 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of skeletal muscle fibre samples from hibernating and awake bears
Description	Recent discoveries in the field of skeletal muscle have found that the contractile protein myosin is able to dictate the resting metabolic rate of this organ. In this study we aimed to investigate if myosin is involved in the process of metabolic shutdown which is observed during hibernation. We found that in small hibernating mammals, the rate of ATP turnover dictated by myosin was altered and that this was also dependent upon the temperature of skeletal muscle. We further investigated changes to the whole proteome of these animals and observed that in small hibernators found significant changes to sarcomere organization during hibernating periods. Finally, we identified hyperphosphorylation upon the myosin molecule in these small hibernators which was predicted to induce stability changes to this molecule.
HostingRepository	PRIDE
AnnounceDate	2024-04-29
AnnouncementXML	Submission_2024-04-29_02:47:48.378.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Wierer
SpeciesList	scientific name: Ursus arctos arctos (European brown bear); NCBI TaxID: 563924;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-11 04:50:18	ID requested
⏵ 1	2024-04-29 02:47:48	announced

10.7554/ELIFE.94616.1;

submitter keyword: uscle, Myosin, Hibernation

Julien Ochala
contact affiliation	University of Copenhagen Department of Biomedical Sciences Blegdamsvej 3B København N, DK-2200
contact email	julien.ochala@sund.ku.dk
lab head
Michael Wierer
contact affiliation	Proteomics Research Infrastructure, University of Copenhagen
contact email	michael.wierer@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD044505

PRIDE project URI

• PRIDE
  1. PXD044505
     1. Label: PRIDE project
     2. Name: Proteomic analysis of skeletal muscle fibre samples from hibernating and awake bears