PXD044499
PXD044499 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Irisin reduces Amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling |
| Description | A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β protein (Aβ) in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but the underlying mechanisms have not been elucidated. Irisin, an exercise-induced hormone, is the secreted form of fibronectin-domain III containing 5 (FNDC5). Here, using a three-dimensional (3D) cell culture model of AD, we show that irisin significantly reduces Aβ pathology by increasing astrocytic release of the Aβ-degrading enzyme neprilysin (NEP). This is mediated by downregulation of ERK-STAT3 signaling. Finally, we show that integrin αV/β5 acts as the irisin receptor on astrocytes required for irisin-induced release of astrocytic NEP, leading to clearance of Aβ. Our findings reveal for the first time a cellular and molecular mechanism by which exercise-induced irisin attenuates Aβ pathology, suggesting a new target pathway for therapies aimed at the prevention and treatment of AD. |
| HostingRepository | iProX |
| AnnounceDate | 2023-08-11 |
| AnnouncementXML | Submission_2024-05-22_20:02:10.217.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Eunhee Kim |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-08-10 21:58:53 | ID requested | |
| 1 | 2023-09-07 19:22:50 | announced | |
| ⏵ 2 | 2024-05-22 20:02:10 | announced | 2024-05-23: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Irisin, Alzheimer's disease, Astrocytes, Neprilysin, ERK, STAT3 |
Contact List
| Se Hoon Choi | |
|---|---|
| contact affiliation | Massachusetts General Hospital |
| contact email | choi.sehoon@mgh.harvard.edu |
| lab head | |
| Eunhee Kim | |
| contact affiliation | Massachusetts General Hospital |
| contact email | ekim43@mgh.harvard.edu |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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