PXD044441

PXD044441 is an original dataset announced via ProteomeXchange.

Title	Long-Term Effects of Omicron BA.2 Breakthrough Infection on Immunity-Metabolism Balance
Description	There have been reports of long coronavirus disease (long COVID) and breakthrough infections (BTIs); however, the mechanisms and pathological features of long COVID after Omicron BTIs remain unclear. Assessing long COVID and immune recovery after Omicron BTIs is crucial for understanding the disease and developing and managing new-generation vaccines. Here, we followed up mild BA.2 BTI convalescents for six-month with routine blood tests and neutralization assay. Then, we applied proteomic analysis and single-cell RNA sequencing (scRNA-seq) to study the convalescents’ recovery status. Lastly, we retrospectively analyzed the clinical parameters related to immunity and metabolism of the convalescents. We found that major organs exhibited ephemeral dysfunction in double-Convidecia vaccinated persons who experienced BA.2 BTI and recovered to normal in approximately six-month. We observed durable and potent levels of neutralizing antibodies against major circulating severe acute respiratory syndrome coronavirus 2 sub-variants, including BQ.1, BQ.1.1 and BF.7, indicating that hybrid humoral immunity stays active. However, PLTs may take longer to recover. This was supported by proteomic and scRNA-seq analyses, which also showed coagulation disorder and an imbalance between anti-pathogen immunity and metabolism six-month after BA.2 BTI. The immunity-metabolism imbalance was then proved with retrospective analysis of abnormal levels of hormones, low blood glucose level and coagulation profile. The long-term malfunctional coagulation and imbalance in the material metabolism and immunity may contribute to the development of long COVID and act as useful indicators for assessing recovery and the long-term impacts after Omicron sub-variant BTIs.
HostingRepository	iProX
AnnounceDate	2023-08-08
AnnouncementXML	Submission_2024-03-26_20:37:52.063.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanhua Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-08 02:18:10	ID requested
1	2023-08-08 02:18:29	announced
2	2024-03-26 00:03:51	announced	2024-03-26: Update information.
⏵ 3	2024-03-26 20:37:53	announced	2024-03-26: Update information. 2024-03-27: Update publication information.

Li Y, Qin S, Dong L, Qiao S, Wang X, Yu D, Gao P, Hou Y, Quan S, Li Y, Fan F, Zhao X, Ma Y, Gao GF, Long-term effects of Omicron BA.2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study. Nat Commun, 15(1):2444(2024) [pubmed]

submitter keyword: SARS-CoV-2, Omicron sub-variant BA.2, breakthrough infection, long COVID

Fu Gao
contact affiliation	Institute of Microbiology, Chinese Academy of Sciences
contact email	gaof@im.ac.cn
lab head
Yanhua Li
contact affiliation	Institute of Microbiology, Chinese Academy of Sciences
contact email	liyh@im.ac.cn
dataset submitter

iProX dataset URI