⮝ Full datasets listing
PXD044426
PXD044426 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dimeric IgA specifically disables intracellular mutated oncodrivers |
| Description | Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we demonstrate that dimeric IgA, but not the same antibody on an IgG backbone, penetrates human epithelial cancer cells through PIGR-dependent directional transcytosis, specifically neutralizing mutated oncodrivers and expelling antigens outside the cell, bound to secretory IgA. Accordingly, targeting of KRASG12D or IDH1R132H with antigen-specific dimeric IgA abrogated the growth of different carcinomas in a mutation-specific manner, including in syngeneic tumor-bearing immunocompetent mice. Our results provide a rationale for developing PIGR-targeting tumor cell-penetrating antibodies to effectively target common mutations in intracellular oncogenes that drive many aggressive and frequent human cancers. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2026-06-12 |
| AnnouncementXML | Submission_2026-06-12_15:17:09.207.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | John Koomen |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-08-07 17:35:52 | ID requested | |
| ⏵ 1 | 2026-06-12 15:17:10 | announced |
Publication List
| Biswas S, Mandal G, Anadon CM, Chaurio RA, Lopez-Bailon LU, Nagy MZ, Mine JA, H, รค, nggi K, Sprenger KB, Innamarato P, Harro CM, Powers JJ, Johnson J, Fang B, Eysha M, Nan X, Li R, Perez BA, Curiel TJ, Yu X, Rodriguez PC, Conejo-Garcia JR, Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers. Immunity, 56(11):2570-2583.e6(2023) [pubmed] |
Keyword List
| submitter keyword: Cancer, immunoglobulin A, Oncogenes |
Contact List
| Jose Conejo-Garcia | |
|---|---|
| contact affiliation | Department of Integrated Immunobiology Duke School of Medicine Durham, NC |
| contact email | jose.conejo-garcia@duke.edu |
| lab head | |
| John Koomen | |
| contact affiliation | Moffitt Cancer Center |
| contact email | john.koomen@moffitt.org |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
