PXD044404

PXD044404 is an original dataset announced via ProteomeXchange.

Title	Preliminary evaluation of the proteomic profiling in the hippocampus of aged grazing cattle
Description	Brain aging is a physiological process associated with physical and cognitive decline; however, in both humans and animals, it that can be regarded as a risk factor for neurodegenerative disorders, such as Alzheimer’s disease. Among several brain regions, hippocampus appears to be more susceptible to detrimental effects of aging. Hippocampus belongs to limbic system and is mainly involved in declarative memories and context-dependent spatial-learning, whose integrity are compromised in an age-dependent manner. In the present work, taking advantage of liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics, we sought to identify proteins differentially expressed in the hippocampus of the aged grazing milk cows. Our exploratory findings showed that 112 proteins were significantly altered in old cattle, when compared to the adult controls, and functional clusterization highlighted their involvement in processes such as myelination, synaptic vesicle, metabolism, and calcium-related pathways. Overall, the present paving the way for the future studies, aimed at better characterizing the role of such a subcortical brain region in the age-dependent cognitive decline across mammals, and identifying early aging markers in farming cattle
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:07:37.664.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Flora Cozzolino
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	(R)-5-oxo-1; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-07 01:12:38	ID requested
1	2024-10-07 13:49:47	announced
⏵ 2	2024-10-22 06:07:38	announced	2024-10-22: Updated project metadata.

10.3389/FNAGI.2023.1274073;

submitter keyword: Aging

Bovine

Brain

Hippocampus

Proteomics

Maria Monti
contact affiliation	Department of Chemical Sciences, University of Naples, Federico II, 80126, Naples, Italy
contact email	montimar@unina.it
lab head
Flora Cozzolino
contact affiliation	University of Naples "Federico II"
contact email	flora.cozzolino@unina.it
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD044404
     1. Label: PRIDE project
     2. Name: Preliminary evaluation of the proteomic profiling in the hippocampus of aged grazing cattle