PXD044398

PXD044398 is an original dataset announced via ProteomeXchange.

Title	PKA R-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast
Description	Toxoplasma gondii is a ubiquitous pathogen of warm-blooded animals and belongs to the phylum of apicomplexan parasites. Apicomplexans cause diseases of high mortality, including toxoplasmosis, malaria, and cryptosporidiosis. Cyclic nucleotide-dependent protein kinases in this divergent family of parasites play crucial roles in pathogenesis and spread. Here, we conduct a phosphoproteomics experiment after T. gondii parasites are depleted of the protein kinase A regulatory subunit (PKA R), resulting in up-regulation of the PKA catalytic subunit 1 (PKA C1).
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:38:34.064.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD044398
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Alice Herneisen
SpeciesList	scientific name: Toxoplasma gondii RH; NCBI TaxID: 383379;
ModificationList	methylthiolated residue; TMTpro; phosphorylated residue; acetylated residue; monohydroxylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-06 13:02:51	ID requested
⏵ 1	2024-10-08 11:38:34	announced

10.7554/ELIFE.93877.1;

10.6019/PXD044398;

submitter keyword: Toxoplasma gondii, T. gondii, phosphoproteomics, parasitology

Sebastian Lourido
contact affiliation	Associate Professor, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
contact email	lourido@wi.mit.edu
lab head
Alice Herneisen
contact affiliation	Whitehead Institute for Biomedical Research, Cambridge, MA, USA 02142 Department of Biology, Massachusetts Insitute of Technology
contact email	alice@wi.mit.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD044398

PRIDE project URI

• PRIDE
  1. PXD044398
     1. Label: PRIDE project
     2. Name: PKA R-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast