PXD044398 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | PKA R-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast |
Description | Toxoplasma gondii is a ubiquitous pathogen of warm-blooded animals and belongs to the phylum of apicomplexan parasites. Apicomplexans cause diseases of high mortality, including toxoplasmosis, malaria, and cryptosporidiosis. Cyclic nucleotide-dependent protein kinases in this divergent family of parasites play crucial roles in pathogenesis and spread. Here, we conduct a phosphoproteomics experiment after T. gondii parasites are depleted of the protein kinase A regulatory subunit (PKA R), resulting in up-regulation of the PKA catalytic subunit 1 (PKA C1). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-08 |
AnnouncementXML | Submission_2024-10-08_11:38:34.064.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD044398 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Alice Herneisen |
SpeciesList | scientific name: Toxoplasma gondii RH; NCBI TaxID: 383379; |
ModificationList | methylthiolated residue; TMTpro; phosphorylated residue; acetylated residue; monohydroxylated residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-06 13:02:51 | ID requested | |
⏵ 1 | 2024-10-08 11:38:34 | announced | |
Publication List
Keyword List
submitter keyword: Toxoplasma gondii, T. gondii, phosphoproteomics, parasitology |
Contact List
Sebastian Lourido |
contact affiliation | Associate Professor, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology |
contact email | lourido@wi.mit.edu |
lab head | |
Alice Herneisen |
contact affiliation | Whitehead Institute for Biomedical Research, Cambridge, MA, USA 02142 Department of Biology, Massachusetts Insitute of Technology |
contact email | alice@wi.mit.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044398
- Label: PRIDE project
- Name: PKA R-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast