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PXD044398

PXD044398 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePKA R-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast
DescriptionToxoplasma gondii is a ubiquitous pathogen of warm-blooded animals and belongs to the phylum of apicomplexan parasites. Apicomplexans cause diseases of high mortality, including toxoplasmosis, malaria, and cryptosporidiosis. Cyclic nucleotide-dependent protein kinases in this divergent family of parasites play crucial roles in pathogenesis and spread. Here, we conduct a phosphoproteomics experiment after T. gondii parasites are depleted of the protein kinase A regulatory subunit (PKA R), resulting in up-regulation of the PKA catalytic subunit 1 (PKA C1).
HostingRepositoryPRIDE
AnnounceDate2024-10-08
AnnouncementXMLSubmission_2024-10-08_11:38:34.064.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD044398
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAlice Herneisen
SpeciesList scientific name: Toxoplasma gondii RH; NCBI TaxID: 383379;
ModificationListmethylthiolated residue; TMTpro; phosphorylated residue; acetylated residue; monohydroxylated residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-06 13:02:51ID requested
12024-10-08 11:38:34announced
Publication List
10.7554/ELIFE.93877.1;
10.6019/PXD044398;
Keyword List
submitter keyword: Toxoplasma gondii, T. gondii, phosphoproteomics, parasitology
Contact List
Sebastian Lourido
contact affiliationAssociate Professor, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
contact emaillourido@wi.mit.edu
lab head
Alice Herneisen
contact affiliationWhitehead Institute for Biomedical Research, Cambridge, MA, USA 02142 Department of Biology, Massachusetts Insitute of Technology
contact emailalice@wi.mit.edu
dataset submitter
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Dataset FTP location
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