PXD044386

PXD044386 is an original dataset announced via ProteomeXchange.

Title	Longitudinal serum proteome analysis in COVID-19
Description	COVID-19 is associated with endotheliopathy and coagulopathy, potentially leading to multi-organ failure. However, the direct mechanisms by which SARS-CoV-2 infection leads to endothelial damage are unclear. Here we developed an infection-competent human vascular organoid from pluripotent stem cells amenable for modeling endotheliopathy. Longitudinal proteome analysis of COVID-19 patient serume was conducted to gain further insights into molecular mediators that drive vascular complications. Differential signatures were identified by comparing late- and early- recovery groups. In the late recovery group, there were significant increases in FCGBP (anti-inflammation), SFTPB (lung surfactant metabolism), coagulation system (A2M and SERPINA1), and complement proteins (C7, CFHR5, and CFD) on day 1-2.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_14:32:56.240.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fuminori Sugihara
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-05 06:16:49	ID requested
⏵ 1	2025-05-06 14:32:57	announced

10.1016/j.stem.2023.09.001;

Kawakami E, Saiki N, Yoneyama Y, Moriya C, Maezawa M, Kawamura S, Kinebuchi A, Kono T, Funata M, Sakoda A, Kondo S, Ebihara T, Matsumoto H, Togami Y, Ogura H, Sugihara F, Okuzaki D, Kojima T, Deguchi S, Vallee S, McQuade S, Islam R, Natarajan M, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Wu Y, Mori K, Hishiki T, Takasaki T, Itoh Y, Takayama K, Nio Y, Takebe T, Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19. Cell Stem Cell, 30(10):1315-1330.e10(2023) [pubmed]

submitter keyword: SARS-CoV-2

endotheliopathy

complement

Takanori Takebe
contact affiliation	Cincinnati Children’s Hospital Medical Center
contact email	takanori.takebe@cchmc.org
lab head
Fuminori Sugihara
contact affiliation	Osaka Univ.
contact email	sugihara@biken.osaka-u.ac.jp
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD044386

PRIDE project URI

• PRIDE
  1. PXD044386
     1. Label: PRIDE project
     2. Name: Longitudinal serum proteome analysis in COVID-19