PXD044372

PXD044372 is an original dataset announced via ProteomeXchange.

Title	Proteomics coupled transcriptomics reveals Slc34a1 and Slc34a3 downregulation as potential features of nephrotoxin-induced acute kidney injury
Description	Acute kidney injury (AKI) is a clinically common and severe disease with a significant economic burden worldwide. Although several studies have focused on the pathogenesis of AKI, much remains unknown about its complex molecular regulatory network and pathophysiological mechanisms. This study combines mass spectrometry and RNA sequencing technologies to investigate nephrotoxin-induced AKI mice's protein and RNA expression profiles. The results revealed that Slc34a1 and Slc34a3 were significantly down-regulated in nephrotoxin-induced AKI mice and may be potential diagnostic and therapeutic targets.
HostingRepository	iProX
AnnounceDate	2023-08-03
AnnouncementXML	Submission_2023-08-04_20:03:36.076.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	jiangbei Yuan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-04 20:03:27	ID requested
⏵ 1	2023-08-04 20:03:36	announced

Dataset with its publication pending

submitter keyword: Quantitative proteomics, RNA sequencing, Acute kidney injury, Slc34a1, Slc34a3, LPS, Cisplatin

jiangbei Yuan
contact affiliation	Peking University Shenzhen Hospital
contact email	yuanjiangbei@163.com
lab head
jiangbei Yuan
contact affiliation	Peking University Shenzhen Hospital
contact email	yuanjiangbei@163.com
dataset submitter

iProX dataset URI