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PXD044334

PXD044334 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleOff-target profiling of Niraparib and Olaparib using Thermal Proteome Profiling
DescriptionExplore off-targets of Niraparib and Olaparib using 2D Thermal Proteome Profiling (2D-TPP)
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_12:45:56.617.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMaria Faelth Savitski
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; methionine oxidation with neutral loss of 64 Da; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF; Orbitrap Fusion Lumos; Orbitrap Exploris 480; Q Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-03 12:24:22ID requested
12025-05-06 12:45:57announced
Publication List
Rutkowska A, Eberl HC, Werner T, Hennrich ML, S, é, vin DC, Petretich M, Reddington JP, Pocha S, Gade S, Martinez-Segura A, Dvornikov D, Karpiak J, Sweetman GMA, Fufezan C, Duempelfeld B, Braun F, Schofield C, Keles H, Alvarado D, Wang Z, Jansson KH, Faelth-Savitski M, Curry E, Remlinger K, Stronach EA, Feng B, Sharma G, Coleman K, Grandi P, Bantscheff M, Bergamini G, Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation. Cancer Res Commun, 4(9):2427-2443(2024) [pubmed]
10.1158/2767-9764.crc-23-0549;
Keyword List
submitter keyword: thermal proteome profiling, PARP, Niraparib,2D-TPP, Olaparib
Contact List
Marcus Bantscheff
contact affiliationCellzome
contact emailmarcus.x.bantscheff@gsk.com
lab head
Maria Faelth Savitski
contact affiliationCellzome
contact emailmaria.x.faelth-savitski@gsk.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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