PXD044308

PXD044308 is an original dataset announced via ProteomeXchange.

Title	Human astrocyte secretome data
Description	In late-onset sporadic Alzheimer’s disease (AD), the most prevalent and strongest risk factor is the ε4 allele of the apolipoprotein E (APOE4). To investigate the pathophysiological effects of the APOE4 genotype in the human cellular context, we generated isogenic iPSC-derived astrocytes bearing APOE4 alleles from APOE3 control iPSC. Next, to identify astrocytic APOE4-specific secreted proteomes, we performed a mass spectrometry using culture media from human astrocytes carrying APOE3 or APOE4.
HostingRepository	jPOST
AnnounceDate	2023-09-01
AnnouncementXML	Submission_2023-08-31_21:54:49.018.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hirotaka Watanabe
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; Acetyl; L-methionine sulfoxide
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-02 19:37:04	ID requested
⏵ 1	2023-08-31 21:54:49	announced

Dataset with its publication pending

submitter keyword: Human, Astrocyte

Hideyuki Okano
lab head
Hirotaka Watanabe
contact affiliation	Keio University
dataset submitter

jPOST dataset URI

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