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PXD044298

PXD044298 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleElucindating the role of the transcription factor IRF4 in Th17 and Treg cells
Description- transcription factor interferon regulatory factor 4 (IRF4) = crucial transcription factor for different immune cells, incl pro-inflammatory Th17 and anti-inflammatory Treg cells - IRF4 is essential for the cell differentiation and fate determination - however molecular mechanisms of IRF4-mediated gene expression in fully differentiated Th17/Treg cells are still not fully understood - integration of data derived from affinity-purification and full mass spectrometry-based proteome analysis with chromatin immune precipitation sequencing (ChIP-Seq) - characterization of proteins generally involved in the T cell development as well as subtype-specific differentiation and identification of novel, yet uncharted IRF4 interactors
HostingRepositoryjPOST
AnnounceDate2024-08-02
AnnouncementXMLSubmission_2024-08-01_08:00:23.301.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnna Gabele
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListS-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
InstrumentOrbitrap Exploris 480; timsTOF Pro 2
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-02 05:18:46ID requested
12024-08-01 08:00:23announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: mouse, Th17 cells, Treg cells, PPI, knockout, LC-MS, DIA-NN
Contact List
Ute Distler, Tobias Bopp
lab head
Anna Gabele
contact affiliationInstitute for Immunology, University Medical Center Mainz
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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