PXD044277

PXD044277 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Interactome analysis of PHF2 using LC-MS combined with an immunoprecipitation assay
Description	PHF2 demethylates lysine 9 in histone 3 and acts as a tumor suppressor. In liver pathogenesis, PHF2 has dual effects. PHF2 induces simple hepato-steatosis by epigenetically coactivating ChREBP. When lipid accumulation goes serious, it protects the liver from fibrogenesis by facilitating Nrf2 activity, a major transcription factor in the defense against oxidative stress during non-alcoholic fatty liver disease. However, little is known regarding the functions of PHF2 in liver cancer cells. Therefore, to investigate the possible roles of PHF2 and find new interacting proteins, we performed an LC-MS/MS assay combined with an immunoprecipitation assay.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:52:29.973.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Do-Won Jeong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-01 19:40:10	ID requested
1	2023-10-17 16:40:00	announced
⏵ 2	2023-11-14 07:52:30	announced	2023-11-14: Updated project metadata.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: LC-MSMS,PHF2, Hepatocellular carcinoma, HepG2

submitter keyword: LC-MSMS,PHF2, Hepatocellular carcinoma, HepG2

Contact List

Yang-Sook Chun
contact affiliation	Seoul National University College of Medicine
contact email	chunys@snu.ac.kr
lab head
Do-Won Jeong
contact affiliation	Seoul National University College of Medicine
contact email	do123@snu.ac.kr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD044277
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD044277

PRIDE project URI

Repository Record List

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