PXD044276

PXD044276 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of human Wharton's jelly mesenchymal stem/stromal cells and human amniotic epithelial stem cells: a comparison of therapeutic potential
Description	Background: Perinatal stem cells have prominent applications in cell therapy and regenerative medicine. Among them, human Wharton's jelly mesenchymal stem/stromal cells (hWJMSCs) and human amniotic epithelial stem cells (hAESCs) are widely used. However, little is known about the dif-ferences in the therapeutic potential of hWJMSCs and hAESCs. Methods: In this study, we reported the phenotypic differences between the two cells and provided the first systematic comparison of their therapeutic potential in terms of immunomodulation, extracellular matrix (ECM) remod-eling, angiogenesis and anti-oxidative stress by means of proteomics. Results: The results showed that the two cells had different protein expression profiles and were both promising candidates for cell therapy. hWJMSCs had a stronger angiogenic potential, while hAESCs had advantages in terms of immune tolerance and antioxidant properties. Notably, hAESCs were found to be enriched in the neurotrophin signaling pathway. Conclusions: Our study provides clues on the choice of cell type in cell therapy for different indications, which will be beneficial in advancing their further clinical translation and application.
HostingRepository	iProX
AnnounceDate	2023-08-02
AnnouncementXML	Submission_2025-05-21_18:45:04.167.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jinying Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ FT

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-01 19:09:51	ID requested
⏵ 1	2025-05-21 18:45:05	announced

Ge Z, Qiu C, Zhou J, Yang Z, Jiang T, Yuan W, Yu L, Li J, Proteomic analysis of human Wharton's jelly mesenchymal stem/stromal cells and human amniotic epithelial stem cells: a comparison of therapeutic potential. Sci Rep, 14(1):28061(2024) [pubmed]

submitter keyword: human amniotic epithelial stem cells, human Wharton's jelly mesenchymal stem cells, proteome, cell therapy, neuroprotection, immunomodulation, ECM remodeling, angiogenesis, anti-oxidative stress, low immunogenicity

Luyang Yu
contact affiliation	Zhejiang University
contact email	luyangyu@zju.edu.cn
lab head
Jinying Li
contact affiliation	Zhejiang University
contact email	jinyingli@zju.edu.cn
dataset submitter

iProX dataset URI