PXD044259

PXD044259 is an original dataset announced via ProteomeXchange.

Title	Proteomic study of Selinexor alleviating bleomycin-induced pulmonary fibrosis
Description	Selinexor is an orally bioavailable, small-molecule selective inhibitor of nuclear export protein that has been approved for the clinical treatment of relapsed or refractory multiple myeloma. At present, some studies have found that Selinexor can play an anti-inflammatory role in sepsis. We found that Selinexor, a selective inhibitor of XPO1, can alleviate bleomycin-induced pulmonary fibrosis in mice in our research work, but the specific mechanism is still unclear. After Selinexor treatment of bleomycin-induced pulmonary fibrosis in mice, we detected some differentially expressed proteins through proteomics, which may be the key mechanism of alleviating pulmonary fibrosis.
HostingRepository	iProX
AnnounceDate	2023-08-01
AnnouncementXML	Submission_2024-06-30_20:53:37.363.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jia Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-01 05:05:20	ID requested
⏵ 1	2024-06-30 20:53:37	announced

Dataset with its publication pending

submitter keyword: proteomics, pulmonary fibrosis, Selinexor, bleomycin

Jia Zhang
contact affiliation	Henan Provincial People's Hospital
contact email	zhangjia1988@zzu.edu.cn
lab head
Jia Zhang
contact affiliation	Henan Provincial People's Hospital
contact email	zhangjia1988@zzu.edu.cn
dataset submitter

iProX dataset URI