PXD044259
PXD044259 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic study of Selinexor alleviating bleomycin-induced pulmonary fibrosis |
Description | Selinexor is an orally bioavailable, small-molecule selective inhibitor of nuclear export protein that has been approved for the clinical treatment of relapsed or refractory multiple myeloma. At present, some studies have found that Selinexor can play an anti-inflammatory role in sepsis. We found that Selinexor, a selective inhibitor of XPO1, can alleviate bleomycin-induced pulmonary fibrosis in mice in our research work, but the specific mechanism is still unclear. After Selinexor treatment of bleomycin-induced pulmonary fibrosis in mice, we detected some differentially expressed proteins through proteomics, which may be the key mechanism of alleviating pulmonary fibrosis. |
HostingRepository | iProX |
AnnounceDate | 2023-08-01 |
AnnouncementXML | Submission_2024-06-30_20:53:37.363.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jia Zhang |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-08-01 05:05:20 | ID requested | |
⏵ 1 | 2024-06-30 20:53:37 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: proteomics, pulmonary fibrosis, Selinexor, bleomycin |
Contact List
Jia Zhang | |
---|---|
contact affiliation | Henan Provincial People's Hospital |
contact email | zhangjia1988@zzu.edu.cn |
lab head | |
Jia Zhang | |
contact affiliation | Henan Provincial People's Hospital |
contact email | zhangjia1988@zzu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |