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PXD044259

PXD044259 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic study of Selinexor alleviating bleomycin-induced pulmonary fibrosis
DescriptionSelinexor is an orally bioavailable, small-molecule selective inhibitor of nuclear export protein that has been approved for the clinical treatment of relapsed or refractory multiple myeloma. At present, some studies have found that Selinexor can play an anti-inflammatory role in sepsis. We found that Selinexor, a selective inhibitor of XPO1, can alleviate bleomycin-induced pulmonary fibrosis in mice in our research work, but the specific mechanism is still unclear. After Selinexor treatment of bleomycin-induced pulmonary fibrosis in mice, we detected some differentially expressed proteins through proteomics, which may be the key mechanism of alleviating pulmonary fibrosis.
HostingRepositoryiProX
AnnounceDate2023-08-01
AnnouncementXMLSubmission_2024-06-30_20:53:37.363.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJia Zhang
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-01 05:05:20ID requested
12024-06-30 20:53:37announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, pulmonary fibrosis, Selinexor, bleomycin
Contact List
Jia Zhang
contact affiliationHenan Provincial People's Hospital
contact emailzhangjia1988@zzu.edu.cn
lab head
Jia Zhang
contact affiliationHenan Provincial People's Hospital
contact emailzhangjia1988@zzu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI