PXD044243

PXD044243 is an original dataset announced via ProteomeXchange.

Title	TMT-based Quantitative Proteomics Identifies Protein Markers of Resistance to Neoadjuvant Chemotherapy in Ovarian Cancer
Description	The high rate of recurrence and chemoresistance necessitates in ovarian cancer warrants further research into tumor markers characterizing the resistant population. The proportion of drug-resistant tissue cells in residual lesions after neoadjuvant chemotherapy increases, and drug-resistant markers are enriched. However, there is a lack of comprehensive understanding of tumor marker predoninance pre- and post- neoadjuvant chemotherapy. Here we performed quantitative proteomic analysis of TMT in three patients with matched pretreatment biopsies and post-NACT ovarian cancer tissues. This study highlights a dominant molecular subpopulation that persists in the ovary after neoadjuvant chemotherapy exposure in order to elucidate how it is involved in mediating chemotherapy response, which will lay the foundation for the development.
HostingRepository	iProX
AnnounceDate	2023-08-01
AnnouncementXML	Submission_2023-07-31_19:54:04.985.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chang Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-31 19:53:43	ID requested
⏵ 1	2023-07-31 19:54:05	announced

Dataset with its publication pending

submitter keyword: ovarian cancer, chemoresistance, proteomics, neoadjuvant chemotherapy

Zhuo Yang
contact affiliation	Cancer Hospital of China Medical University
contact email	yangzhuo@cancerhosp-ln-cmu.com
lab head
Chang Liu
contact affiliation	Liaoning Cancer Hospital and Institute
contact email	liuchang@cmu.edu.cn
dataset submitter

iProX dataset URI