PXD044120

PXD044120 is an original dataset announced via ProteomeXchange.

Title	Assesment of Peripheral Blood Mononuclear Cells Responce Exposed to Staphylococcus aureus Biofilms and Planktonic Bacteria
Description	Staphylococcus aureus is one of the most successful human pathogens. It is the leading cause of a multitude of healthcare-associated, community-acquired, and acute-to-chronic infectious diseases. Bacteria can benefit from host signals during infection. Immune cells such as monocytes are able to secrete chemokine upon facing planktonic bacteria or their products. Host immune regulatory chemokine is capable to trigger planktonic S. aureus to releases its virulence factor to evade the immune response. Chemokine binding may facilitate immune evasion by S. aureus, however, the biofilm ability to induce chemokine secretion remains unknown. Also, Understanding the immune response to biofilms is critical for developing effective diagnostics and treatments for biofilm associated infections, as bacteria in biofilms differ in their resistance to antibiotics and host immune response.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:29:57.186.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Reza Gheitasi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-26 18:17:10	ID requested
1	2024-02-15 01:41:09	announced
⏵ 2	2024-10-22 06:29:57	announced	2024-10-22: Updated project metadata.

10.3389/FIMMU.2024.1334616;

submitter keyword: proteomics, immune response, chemokines,Chronic infections, secretome, interleukins

Mathias M. Pletz
contact affiliation	Institute of Infectious Diseases and Infection Control, Jena University Hospital / Friedrich Schiller University, Jena, 07747, Germany.
contact email	Mathias.Pletz@med.uni-jena.de
lab head
Reza Gheitasi
contact affiliation	Jena University Hospital
contact email	reza.gheitasi@med.uni-jena.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD044120

PRIDE project URI

• PRIDE
  1. PXD044120
     1. Label: PRIDE project
     2. Name: Assesment of Peripheral Blood Mononuclear Cells Responce Exposed to Staphylococcus aureus Biofilms and Planktonic Bacteria