PXD044118 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling |
| Description | Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been assumed that elevated PT at young ages is beneficial to health and PT ends up dropping as a passive byproduct of aging. In Drosophila, we show that a transient elevation in PT during early-adulthood exerts long-lasting negative impacts on aging trajectories and proteostasis in later-life. Blocking the early-life PT elevation robustly improves life-/health-span and prevents age-related protein aggregation, whereas transiently inducing an early-life PT surge in long-lived fly strains abolishes their longevity/proteostasis benefits. The early-life PT elevation triggers proteostatic dysfunction, silences stress responses, and drives age related functional decline via juvenile hormone-lipid transfer protein axis and germline signaling. Our findings suggest that PT is adaptively suppressed after early-adulthood, alleviating later-life proteostatic burden, slowing down age-related functional decline, and improving lifespan. Our work provides a theoretical framework for understanding how lifetime PT dynamics shape future aging trajectories. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_06:07:43.101.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD044118 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | james mobley |
| SpeciesList | scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-07-26 17:04:04 | ID requested | |
| 1 | 2023-10-24 09:36:13 | announced | |
| 2 | 2023-11-14 09:06:33 | announced | 2023-11-14: Updated project metadata. |
| ⏵ 3 | 2024-10-22 06:07:43 | announced | 2024-10-22: Updated project metadata. |
Publication List
| Kim HS, Parker DJ, Hardiman MM, Munk, รก, csy E, Jiang N, Rogers AN, Bai Y, Brent C, Mobley JA, Austad SN, Pickering AM, Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling. Nat Commun, 14(1):5021(2023) [pubmed] |
| 10.1038/s41467-023-40618-x; |
| 10.6019/PXD044118; |
Keyword List
| submitter keyword: Proteostasis, Aging,Proteomics, LCMS2, Drosophila |
Contact List
| James A Mobley |
|---|
| contact affiliation | Director UAB Proteomics Facility, Professor UAB Anesthesiology |
| contact email | mobleyja@uab.edu |
| lab head | |
| james mobley |
|---|
| contact affiliation | University of Alabama at Birmingham |
| contact email | mobleyja@uab.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD044118 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044118
- Label: PRIDE project
- Name: Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling
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