PXD044108

PXD044108 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Signature Profiling in the Cortex of Dairy Cattle Un-ravProteomic Signature Profiling in the Cortex of Dairy Cattle Un-ravels the Physiology of Brain Aging els the Physiology of Brain Aging
Description	Aging is a physiological process occurring in all living organisms. It is characterized by a pro-gressive deterioration of the physiological and cognitive functions of the organism, accompanied by a gradual impairment of mechanisms involved in the regulation of tissue and organ homeo-stasis, thus exacerbating the risk of developing pathologies, including cancer and neurodegener-ative disorders. In the present work, we sought to investigate the influence of aging upon the expression protein profile in the brain cortex of grazing cattle, through LC-MS/MS-based differ-ential proteomics and bioinformatic analysis approach. We found a significant downregulation of proteins involved in synaptic plasticity, myelination, dendritic process, and oxidative stress in the cortex of aged bovine when compared to the adult samples. In conclusion, our data pave the way for a better understanding of molecular mechanisms underlying brain aging in cattle.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:16:01.511.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Flora Cozzolino
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	(R)-5-oxo-1; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-26 08:17:00	ID requested
1	2024-10-07 13:49:37	announced
⏵ 2	2024-10-22 06:16:01	announced	2024-10-22: Updated project metadata.

Publication List

10.3389/FNAGI.2023.1277546;

10.3389/FNAGI.2023.1277546;

Keyword List

submitter keyword: Bovine
Brain
Cortex
Aging
Proteomics

submitter keyword: Bovine

Brain

Cortex

Aging

Proteomics

Contact List

Maria Monti
contact affiliation	Department of Chemical Sciences, University of Naples, Federico II, 80126, Naples, Italy
contact email	montimar@unina.it
lab head
Flora Cozzolino
contact affiliation	University of Naples "Federico II"
contact email	flora.cozzolino@unina.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD044108
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD044108

PRIDE project URI

Repository Record List

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