PXD044084

PXD044084 is an original dataset announced via ProteomeXchange.

Title	Profiling protein-protein interactions in human brain by refined co-fractionation mass spectrometry
Description	Proteins are essential regulators of biological processes and can have diverse functions depending on their interactions with other proteins. To understand deeply the interaction and their complexes, co-fractionation mass spectrometry (CF-MS) was used with ion exchange chromatography columns and data was analyzed with Data-independent acquisition (DIA) mode. Our comprehensive DIA CF-MS analysis successfully identified over 1,000 protein complexes and approximately 10,000 protein-protein interactions, many of which had not been previously discovered. These findings present an invaluable resource for a wide range of human brain research endeavors, including the identification of disease-specific protein complexes.
HostingRepository	PRIDE
AnnounceDate	2024-03-21
AnnouncementXML	Submission_2024-03-21_07:31:23.213.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Donggeun Lee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-25 15:38:34	ID requested
⏵ 1	2024-03-21 07:31:23	announced

10.1021/ACS.JPROTEOME.3C00685;

submitter keyword: protein-protein interaction, co-fractionation mass spectrometry, data-independent acquisition

DongGeun Lee
contact affiliation	St.Jude Children's Research Hospital
contact email	donggeun.lee@stjude.org
lab head
Donggeun Lee
contact affiliation	St.Jude Children's Research Hospital
contact email	donggeun.lee@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD044084

PRIDE project URI

• PRIDE
  1. PXD044084
     1. Label: PRIDE project
     2. Name: Profiling protein-protein interactions in human brain by refined co-fractionation mass spectrometry