PXD044083 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Profiling protein-protein interactions in human brain by refined co-fractionation mass spectrometry |
Description | Proteins are essential regulators of biological processes and can have diverse functions depending on their interactions with other proteins. To understand deeply the interaction and their complexes, co-fractionation mass spectrometry (CF-MS) was used with ion exchange chromatography columns and data was analyzed with Data-independent acquisition (DIA) mode. Our comprehensive DIA CF-MS analysis successfully identified over 1,000 protein complexes and approximately 10,000 protein-protein interactions, many of which had not been previously discovered. These findings present an invaluable resource for a wide range of human brain research endeavors, including the identification of disease-specific protein complexes. |
HostingRepository | PRIDE |
AnnounceDate | 2024-03-21 |
AnnouncementXML | Submission_2024-03-21_08:08:47.570.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Donggeun Lee |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-25 14:50:07 | ID requested | |
⏵ 1 | 2024-03-21 08:08:47 | announced | |
Publication List
Keyword List
submitter keyword: protein-protein interaction, co-fractionation mass spectrometry, data-independent acquisition |
Contact List
DongGeun Lee |
contact affiliation | St. Jude Children's Research Hospital |
contact email | donggeun.lee@stjude.org |
lab head | |
Donggeun Lee |
contact affiliation | St.Jude Children's Research Hospital |
contact email | donggeun.lee@stjude.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD044083 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044083
- Label: PRIDE project
- Name: Profiling protein-protein interactions in human brain by refined co-fractionation mass spectrometry