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PXD044045

PXD044045 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic characterization of extracellular vesicles (EVs) released by primary human vascular smooth muscle cells (VSMCs) under calcification stress
DescriptionVascular calcification (VC) is a strong predictor of cardiovascular risk, particularly in chronic kidney disease (CKD) patients, associated with increased vascular stiffness, pulse pressure, left ventricular hypertrophy and atherosclerotic plaque burden [1]. VC is currently accepted as a highly controlled multifactorial process, where the release of extracellular vesicles (EVs) with calcification capacity plays an essential role in mediating cell-induced matrix mineralization [2]. Still, questions considering mechanisms of EVs deposition in the extracellular space, and its relationship with vesicle origin, loading, calcifying capacity and role in intercellular communication remain elusive. In this work we established a proteomic approach to characterize extracellular matrix (ECM)-deposited and cell media (CM) released EVs, from an in vitro model of VC consisting of primary vascular smooth muscle cells (VSMCs), bringing new knowledge into their specific characteristics and cargo.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_10:13:59.309.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD044045
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterTeresa Mendes Maia
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-24 08:54:17ID requested
12025-05-06 10:14:00announced
Publication List
10.6019/PXD044045;
10.3390/ijms252212406;
Viegas C, Carreira J, Maia TM, Macedo AL, Matos AP, Neves J, Simes D, Gla Rich Protein (GRP) Mediates Vascular Smooth Muscle Cell (VSMC) Osteogenic Differentiation, Extracellular Vesicle (EV) Calcification Propensity, and Immunomodulatory Properties. Int J Mol Sci, 25(22):(2024) [pubmed]
Keyword List
submitter keyword: Human
Vascular smooth muscle cells (VSMCs)
vascular calcification
LC-MSMS
Contact List
Carla Viegas; Dina Simes
contact affiliationUniversity of Algarve, Centre of Marine Sciences (CCMAR), Campus de Gambelas, 8005-139 Faro, Portugal
contact emaildsimes@ualg.pt
lab head
Teresa Mendes Maia
contact affiliationVIB Proteomics Core
contact emailteresa.maia@vib-ugent.be
dataset submitter
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Dataset FTP location
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