PXD043970
PXD043970 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mechanistic Insight into Glioma Through Spatially Multidimensional Proteomics |
| Description | Characterizing the tumor microenvironment at the molecular level is essential for understanding the mechanisms of tumorigenesis and evolution. However, the specificity of the blood proteome in localized region of the tumor and its linkages with other systems is difficult to investigate. Here, we propose a spatially multidimensional comparative proteomics strategy using glioma as an example. The blood proteome signature of tumor microenvironment was specifically identified by in situ collection of arterial and venous blood from the glioma region of the brain for comparison with peripheral blood. And by integrating with different dimensions of tissue and peripheral blood proteomics, the information on the genesis, migration and exchange of glioma-associated proteins was revealed, which provided a powerful method for tumor mechanism research and biomarker discovery. The study recruited multidimensional clinical cohorts, allowing the proteomic results to corroborate each other, reliably revealing biological processes specific to gliomas and identifying highly accurate biomarkers. |
| HostingRepository | iProX |
| AnnounceDate | 2023-07-20 |
| AnnouncementXML | Submission_2024-02-22_20:02:56.814.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhourui Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-07-20 19:43:14 | ID requested | |
| ⏵ 1 | 2024-02-22 20:02:57 | announced |
Publication List
| Shen L, Zhang Z, Wu P, Yang J, Cai Y, Chen K, Chai S, Zhao J, Chen H, Dai X, Yang B, Wei W, Dong L, Chen J, Jiang P, Cao C, Ma C, Xu C, Zou Y, Zhang J, Xiong W, Li Z, Xu S, Shu B, Wang M, Li Z, Wan Q, Xiong N, Chen S, Mechanistic insight into glioma through spatially multidimensional proteomics. Sci Adv, 10(7):eadk1721(2024) [pubmed] |
Keyword List
| submitter keyword: Glioma, spatially specific plasma samples, muti-cohorts, proteomics |
Contact List
| Suming Chen | |
|---|---|
| contact affiliation | The Institute for Advanced Studies, Wuhan University |
| contact email | chensm@iccas.ac.cn |
| lab head | |
| Zhourui Zhang | |
| contact affiliation | The Institute for Advanced Studies, Wuhan University |
| contact email | 18794831171@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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