PXD043968

PXD043968 is an original dataset announced via ProteomeXchange.

Title	Breeding from 1891 to 2010 did not increase the content of amylase/trypsin-inhibitors in wheat (Triticum aestivum L.)
Description	The prevalence of hypersensitivities towards wheat has increased in the last decades. Apart from celiac disease these include allergic and other inflammatory reactions summarized under the term non-celiac wheat sensitivity. One suspected trigger is the family of amylase/trypsin-inhibitors (ATIs), non-gluten proteins that are prominent wheat allergens and that activate the toll-like receptor 4 on intestinal immune cells to promote intestinal and extra-intestinal inflammation. We therefore quantified 13 ATIs in 60 German hexaploid winter wheat cultivars originating from 1891 to 2010 and harvested in three years by targeted liquid chromatography-tandem mass spectrometry combined with stable isotope dilution assay using specific marker peptides as internal standards. The total ATI content and that of the two major ATIs 0.19 and CM3 did not change from old cultivars (first registered from 1891–1950) to modern cultivars (1951–2010). There were also no significant changes in ATI distribution.
HostingRepository	PanoramaPublic
AnnounceDate	2023-09-01
AnnouncementXML	Submission_2023-09-01_15:13:02.763.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	supported by repository but incomplete data and/or metadata
PrimarySubmitter	Sabrina Geisslitz
SpeciesList	scientific name: Triticum aestivum; NCBI TaxID: 4565;
ModificationList	Gln->pyro-Glu; Carbamidomethyl; Label:13C(6)15N(2); Label:13C(5)15N(1); Label:13C(6)15N(4); Label:13C(6)15N(1)
Instrument	TSQ Vantage

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-20 17:47:57	ID requested
1	2023-08-29 11:46:20	announced
⏵ 2	2023-09-01 15:13:03	announced	: Added PubMed Id

Geisslitz S, Pronin D, Neerukonda M, Curella V, Neufang S, Koch S, Weichert H, Weber H, B, ö, rner A, Schuppan D, Scherf KA, Breeding from 1891 to 2010 did not increase the content of amylase/trypsin-inhibitors in wheat (Triticum aestivum). NPJ Sci Food, 7(1):43(2023) [pubmed]

submitter keyword: Amylase/trypsin-inhibitors (ATIs), Heritability, non-celiac gluten sensitivity (NCGS), non-celiac wheat sensitivity (NCWS), stable isotope dilution assay (SIDA), wheat allergy

Katharina Scherf
contact affiliation	Karlsruhe Institute of Technology
contact email	katharina.scherf@kit.edu
lab head
Sabrina Geisslitz
contact affiliation	Karlsruhe Institute of Technology
contact email	sabrina.geisslitz@kit.edu
dataset submitter

Panorama Public dataset URI