PXD043959

PXD043959 is an original dataset announced via ProteomeXchange.

Title	Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles
Description	We performed quantitative label-free quantitative mass spectrometry (LFQ-MS) on 16 cell lysates and 16 EV lysates derived from BV2 microglia. These included four groups of BV2 cells (n=4/group) that were treated (72 hours) with either LPS (100ng/mL) to polarize to a pro-inflammatory state, IL-10 (50ng/mL) to polarize to a protective state, TGFβ (50ng/mL) to polarize to a homeostatic state or untreated controls
HostingRepository	PRIDE
AnnounceDate	2023-11-21
AnnouncementXML	Submission_2023-11-21_11:35:39.850.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juliet Santiago
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; acetylated residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-20 09:28:21	ID requested
⏵ 1	2023-11-21 11:35:40	announced

10.1016/j.mcpro.2023.100678;

Santiago JV, Natu A, Ramelow CC, Rayaprolu S, Xiao H, Kumar V, Kumar P, Seyfried NT, Rangaraju S, Identification of State-Specific Proteomic and Transcriptomic Signatures of Microglia-Derived Extracellular Vesicles. Mol Cell Proteomics, 22(12):100678(2023) [pubmed]

submitter keyword: neuroinflammation, proteomics, mass spectrometry,Extracellular vesicles, microglia, transcriptomics, RNA sequencing

Srikant Rangaraju
contact affiliation	Associate Professor, Deparment of Neurology, Emory University
contact email	srikant.rangaraju@emory.edu
lab head
Juliet Santiago
contact affiliation	Emory University
contact email	jvsanti@emory.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD043959

PRIDE project URI

• PRIDE
  1. PXD043959
     1. Label: PRIDE project
     2. Name: Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles