PXD043922

PXD043922 is an original dataset announced via ProteomeXchange.

Title	In-depth proteome analysis of renal fibrosis in primary cultured human-derived kidney cells
Description	Biomarker assessments based on kidney tissue evaluations show a direct correlation with renal fibrosis, but are limited by their invasive nature. Consequently, there is a growing interest in noninvasive biomarkers based on urine and blood samples. However, the utility of urine samples is limited by variations in concentrations and challenges in determining the specific origin of the detected substances, while blood samples may reflect changes in multiple organs, complicating biomarker evaluations. To address these issues, we performed a proteomics study to identify potential biomarkers of renal fibrosis using primary cultured human-derived kidney cells.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_10:38:26.717.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dohyun Han
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-19 09:57:50	ID requested
⏵ 1	2025-05-06 10:38:28	announced

Kwon S, Cheon S, Kim KH, Seo A, Bae E, Lee JW, Cha RH, Hwang JH, Kim YC, Kim DK, Kim YS, Han D, Yang SH, Unveiling the role of transgelin as a prognostic and therapeutic target in kidney fibrosis via a proteomic approach. Exp Mol Med, 56(10):2296-2308(2024) [pubmed]

10.1038/s12276-024-01319-7;

submitter keyword: hTEC,TMT, renal fibrosis

Dohyun Han
contact affiliation	Proteomics core facility, Biomedicial Research Institute, Seoul National University Hospital
contact email	hdh03@snu.ac.kr
lab head
Dohyun Han
contact affiliation	Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital
contact email	hdh03@snu.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD043922

PRIDE project URI

• PRIDE
  1. PXD043922
     1. Label: PRIDE project
     2. Name: In-depth proteome analysis of renal fibrosis in primary cultured human-derived kidney cells