PXD043897

PXD043897 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of global response to ionizing radiation in Hypsibius exemplaris
Description	Recent studies have shown that proteins unique to tardigrades are involved in the remarkable ability of these small animals to withstand desiccation and ionizing radiation (IR). For resistance to IR, only one tardigrade unique protein has been identified so far: Dsup, for DNA damage suppressor, found in R. varieornatus and H. exemplaris. Rv-Dsup protects from DNA damage by X-rays in human cells, suggesting that DNA protection is important for resistance to IR. Here, we chose to investigate the role of DNA repair and search for novel tardigrade unique genes involved in resistance to IR. For this, we performed an unbiased proteome analysis of H. exemplaris either untreated, or at 4h post-irradiation, 24h post-irradiation and after Bleomycin treatment.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:45:58.065.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Hypsibius exemplaris; NCBI TaxID: 2072580;
ModificationList	alkylated residue; acetylated residue; monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-19 03:06:30	ID requested
1	2024-06-17 06:17:49	announced
⏵ 2	2024-10-22 06:45:58	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: isobaric labeling,Tardigrade, ionizing radiation, nanoLC-MS/MS

Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
lab head
Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043897
     1. Label: PRIDE project
     2. Name: Proteomic analysis of global response to ionizing radiation in Hypsibius exemplaris