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PXD043889

PXD043889 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLncRNA DGCR5-encoded polypeptide RIP aggravates steroid-induced osteonecrosis of the femoral head by repressing nuclear localization of β-catenin in BMSCs
DescriptionThe differentiation fate of bone marrow mesenchymal stem cells (BMSCs) affects the progression of steroid-induced osteonecrosis of the femoral head (SONFH). We find that LncRNA DGCR5 encodes a 102-aa polypeptide, RIP (Rac1 inactivated peptide), which promotes the adipogenic differentiation of BMSCs and aggravates the progression of SONFH. RIP, instead of LncRNA DGCR5, binds to the N-terminal motif of RAC1 and inactivates the RAC1/PAK1 cascade, resulting in decreased Ser675 phosphorylation of β-catenin. Ultimately, the nuclear localization of β-catenin decreases, and the differentiation balance of BMSCs tilts toward the adipogenesis lineage. In the femoral head of rats, overexpression of RIP causes trabecular bone disorder and adipocyte accumulation, which can be rescued by overexpressing RAC1. This finding expands the regulatory role of lncRNAs in BMSCs and suggests RIP as a potential therapeutic target.
HostingRepositoryiProX
AnnounceDate2023-07-19
AnnouncementXMLSubmission_2023-07-19_00:16:02.298.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterWeiqian Jiang
SpeciesList scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationListNo PTMs are included in the dataset
Instrument4800 Plus MALDI TOF/TOF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-19 00:08:48ID requested
12023-07-19 00:16:02announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: SONFH, LncRNA, peptide
Contact List
Jian Zhang
contact affiliationThe First Affiliated Hospital of Chongqing Medical University
contact emailzhangjian@hospital.cqmu.edu.cn
lab head
Weiqian Jiang
contact affiliationThe First Affiliated Hospital of Chongqing Medical University
contact emailzerojwq@stu.cqmu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI