PXD043874

PXD043874 is an original dataset announced via ProteomeXchange.

Title	Elucidation of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma
Description	A comprehensive systemic assessment of the proteome changes that occur in prostate cancer (PCa) during the onset and course of the illness may produce results that are clinically significant. Proteins, the main participants in the majority of biological events, are both potential biomarkers and therapeutic targets. Although the PCa tissue proteome has already been described, screening tissue samples is an intrusive operation. As a result, we concentrated on liquid biopsies like urine samples for this investigation. Specifically, liquid chromatography coupled to high-resolution mass spectrometry (LC-MS/MS) was employed to examine the urinary small extracellular vesicle (EV) proteome patterns of 100 patients. The main objective of this study is to identify biomarkers for PCa patients with cribriform pattern and intraductal PCa (IDC).
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_10:36:19.565.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD043874
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Rune Matthiesen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-18 15:19:55	ID requested
⏵ 1	2025-05-06 10:36:20	announced

Bernardino R, Carvalho AS, Hall MJ, Alves L, Le, ã, o R, Sayyid R, Pereira H, Beck HC, Pinheiro LC, Henrique R, Fleshner N, Matthiesen R, Profiling of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma in a cross-sectional study. Sci Rep, 14(1):25065(2024) [pubmed]

10.1038/s41598-024-75272-w;

10.6019/PXD043874;

submitter keyword: intraductal prostate carcinoma, proteomics, cribriform,liquid chromatography mass spectrometry, urinary extracellular vesicles

Rune Matthiesen
contact affiliation	Computational and Experimental Biology Group, NOVA Medical School-Research, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisbon, Portugal.
contact email	runem2009@gmail.com
lab head
Rune Matthiesen
contact affiliation	Computational and Experimental Biology Group, CEDOC NOVA MEDICAL SCHOOL / FACULDADE DE CIÊNCIAS MÉDICAS UNIVERSIDADE NOVA DE LISBOA Rua Câmara Pestana, 6-6A | 1150-082 Lisboa Portugal
contact email	runem2009@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043874
     1. Label: PRIDE project
     2. Name: Elucidation of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma