PXD043872

PXD043872 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic dissection of Vanishing white matter pathogenesis
Description	We aimed at gaining more insight into the molecular basis of VWM pathogenesis. Therefore we investigated protein expression patterns in the 2b5ho mouse model using a data-independent mass spectrometry-based quantitative proteomic analysis. The proteome of 4 different brain regions was analyzed at different time points of disease progression. Brain regions were selected based on their regional vulnerability to VWM, and included the cerebellum, corpus callosum, cortex, and brainstem. Commonalities and differences in proteome changes between 2b5ho mouse and VWM patient brains were assessed to determine disease-relevant protein changes during disease development and progression.
HostingRepository	PRIDE
AnnounceDate	2024-06-16
AnnouncementXML	Submission_2024-06-16_10:09:10.019.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peter Robert Mosen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized amino-terminal residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-18 11:44:02	ID requested
⏵ 1	2024-06-16 10:09:10	announced

Publication List

Man JHK, Zarekiani P, Mosen P, de Kok M, Debets DO, Breur M, Altelaar M, van der Knaap MS, Bugiani M, Proteomic dissection of vanishing white matter pathogenesis. Cell Mol Life Sci, 81(1):234(2024) [pubmed]
10.1007/s00018-024-05258-4;

Man JHK, Zarekiani P, Mosen P, de Kok M, Debets DO, Breur M, Altelaar M, van der Knaap MS, Bugiani M, Proteomic dissection of vanishing white matter pathogenesis. Cell Mol Life Sci, 81(1):234(2024) [pubmed]

10.1007/s00018-024-05258-4;

Keyword List

submitter keyword: Quantitative proteomics, Brain, Leukodystrophy,Vanishing white matter, Disease progression

submitter keyword: Quantitative proteomics, Brain, Leukodystrophy,Vanishing white matter, Disease progression

Contact List

Marianna Bugiani
contact affiliation	Department of Pathology, Amsterdam UMC, Vrije UniversiteitAmsterdam, Amsterdam, The Netherlands
contact email	m.bugiani@amsterdamumc.nl
lab head
Peter Robert Mosen
contact affiliation	Utrecht University Biomolecular Mass Spectrometry and Proteomics Padualaan 8, 3584 CH Utrecht
contact email	p.r.mosen@uu.nl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043872
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043872

PRIDE project URI

Repository Record List

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