PXD043828

PXD043828 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis reveals the neurotoxic effects of chronic methamphetamine self-administration-induced cognitive impairments and the role of melatonin-enhanced restorative process during drug withdrawal.
Description	, this study aimed to investigate the mechanisms underlying neuropathological processes related to cognitive impairment in mice chronically-treated with METH. In addition, the effective melatonin on recovery of neurological dysfunction and neurobehavioral deficits during METH withdrawal was also investigated. Cognitive function was evaluated in mice after chronic METH administration and METH withdrawal, and the effect of melatonin treatment during the withdrawal phase on cognitive function was also assessed. In addition, the profile of proteins related to mitochondrial and neurological functions in PFC was determined using proteomic and western blot analysis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:13:14.915.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tanthai Polvat
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	compact

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-16 23:10:28	ID requested
1	2023-10-24 15:24:56	announced
2	2023-11-14 09:12:45	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:13:19	announced	2024-10-22: Updated project metadata.

10.1021/acs.jproteome.3c00502;

Polvat T, Prasertporn T, Na Nakorn P, Pannengpetch S, Suwanjang W, Panmanee J, Ngampramuan S, Cornish JL, Chetsawang B, Proteomic Analysis Reveals the Neurotoxic Effects of Chronic Methamphetamine Self-Administration-Induced Cognitive Impairments and the Role of Melatonin-Enhanced Restorative Process during Methamphetamine Withdrawal. J Proteome Res, 22(10):3348-3359(2023) [pubmed]

submitter keyword: mitophagy, cognitive function,methamphetamine, neurotoxicity, mitochondria, neuroplasticity, drug addiction, neurodegeneration, proteomics., melatonin

Tanthai Polvat
contact affiliation	Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, 73170, Thailand.
contact email	tanthai.pov@student.mahidol.ac.th
lab head
Tanthai Polvat
contact affiliation	Mahidol University
contact email	tanthai.pov@student.mahidol.ac.th
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD043828

PRIDE project URI

• PRIDE
  1. PXD043828
     1. Label: PRIDE project
     2. Name: Proteomic analysis reveals the neurotoxic effects of chronic methamphetamine self-administration-induced cognitive impairments and the role of melatonin-enhanced restorative process during drug withdrawal.